Auswahl von Publikationen aus dem Konsiliarlabor Diphtherie

Molekulare Charakterisierung

  • Dangel, A., A. Berger, J. Rau, T. Eisenberg, P. Kämpfer, G. Margos, M. Contzen, H.-J. Busse, R. Konrad, M. Peters, R. Sting, and A. Sing. 2020. Corynebacterium silvaticum sp. nov., a unique group of NTTB corynebacteria in wild boar and roe deer. Int J Syst Evol Microbiol. 70: 3614-3624
  • Rau, J., T. Eisenberg, M. Peters, A. Berger, P. Kutzer, H. Lassnig, H. Hotzel, A. Sing, R. Sting, and M. Contzen. 2019. Reliable differentiation of a non-toxigenic tox gene-bearing Corynebacterium ulcerans variant frequently isolated from game animals using MALDI-TOF MS. Vet Microbiol. 237:108399
  • Möller, J., M. Kraner, U. Sonnewald, V. Sangal, H. Tittlbach, J. Winkler, T.H. Winkler, V. Melnikov, R. Lang, A. Sing, A.L. Mattos-Guaraldi, and A. Burkovski. 2019. Proteomics of diphtheria toxoid vaccines reveals multiple proteins that are immunogenic and may contribute to protection of humans against Corynebacterium diphtheriae. Vaccine 37:3061-3070
  • Dangel, A., A. Berger, R. Konrad, and A. Sing. 2019. NGS-based phylogeny of diphtheria-related pathogenicity factors in different Corynebacterium spp. implies species-specific virulence transmission. BMC Microbiol.;19: 28
  • Meinel, D.M., G. Margos, R. Konrad, S. Krebs, H. Blum, and A. Sing. Next generation sequencing analysis of nine Corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin encoding pathogenicity island. Genome Medicine 2014; 6: 113
  • König, C., D.M. Meinel, G. Margos, R. Konrad, and A. Sing. Multilocus Sequence Typing of Corynebacterium ulcerans provides evidence for zoonotic transmission and for increased prevalence of certain sequence types among toxigenic strains. J Clin Microbiol. 2014; 52:4318-4324
  • Bolt, F., P. Cassiday, M.L.Tondella, A. DeZoysa, A. Efstratiou, A. Sing, A. Zasada, K. Bernard, N. Guiso, E. Badell, M-L. Rosso, A. Baldwin, C. Dowson. Multilocus sequence typing identifies of evidence recombination and two distinct lineages within Corynebacterium diphtheriae. J. Clin. Microbiol. 2010; 48: 4177-4185
  • Sing, A., S. Bierschenk, and J. Heesemann. Classical diphtheria caused by Corynebacterium ulcerans in Germany: amino acid sequence differences between diphtheria toxins from C. diphtheriae and C. ulcerans. Clin. Infect. Dis. 2005; 40: 325-326
  • Sing, A., M. Hogardt, S. Bierschenk, and J. Heesemann. Detection of differences in the nucleotide and aminoacid sequences of diphtheria toxin from Corynebacterium diphtheriae and Corynebacterium ulcerans causing extrapharyngeal infections. J. Clin. Microbiol. 2003; 41: 4848-4851


  • WHO laboratory manual for the diagnosis of diphtheria and other related infections. World Health Organization
  • Marosevic, D., A. Berger, G. Kahlmeter, S. Payer, S. Hörmansdorfer, and A. Sing. 2020. Antimicrobial susceptibility of Corynebacterium diphtheriae and C. ulcerans in Germany 2011-2017. J Antimicrob Chemother 75: 2885-2893
  • Both, L, S. Neal, A.De Zoysa, G. Mann, I. Czumbel, A. Efstratiou, and Members of the European Diphtheria Surveillance Network. External quality assessments for microbiologic diagnosis of Diphtheria in Europe. J Clin Microbiol. 2014; 52:4381-4384
  • Von Hunolstein, C., L. Ralli, A. Pinto, P. Stickings, A. Efstratiou, I. Czumbel, A. Decheva, R, et al. Relevance and Criticality in an External Quality Assessment for the Determination of Diphtheria Antitoxin. J Immunol Clin Res 2014; 2(2): 1022
  • Berger, A., M. Hogardt, R. Konrad, and A. Sing. 2014. Detection methods for laboratory diagnosis of diphtheria. In: Burkovski, A. (ed.), Corynebacterium diphtheriae and related toxigenic species. Genomics, Pathogenicity and Applications. Springer-Verlag, Berlin-Heidelberg; p. 171-205
  • Sing, A., A. Berger, W. Schneider-Brachert, T. Holzmann, and U. Reischl. Rapid detection and molecular differentiation of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by LightCycler PCR. J. Clin. Microbiol. 2011; 49: 2485-2489
  • Berger, A., and A. Sing. 2010. Corynebacterium diphtheriae. In: Podbielski, A., A. Berger, S. Dommerich, M. Donat, H. Frickmann, W. Hampl, M. Hermann, H. Lang, H. Luckhaupt, M. Riffelmann, A. Sing, A. Spahr, U. Vogel, C. Wirsing von König: Mikrobiologisch-infektiologische Qualitätsstandards (MiQ) 13a und 13b: Infektionen des Mundes und der oberen Atemwege, Teil I und II . 2. neu bearbeitete Aufl., p 107-113
  • Konrad, R., A. Berger, I. Huber, V. Boschert, S. Hörmansdorfer, U. Busch, M. Hogardt, S. Schubert, and A. Sing. 2010. Matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) mass spectrometry as a tool for rapid diagnosis of potentially toxigenic Corynebacterium species in the laboratory management of diphtheria-associated bacteria. Euro Surveill 15: pii=19699
  • Schuhegger, R., M. Lindermayer, R. Kugler, J. Heesemann, U. Busch, and A. Sing. Detection of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by a novel real-time PCR. J. Clin. Microbiol. 2008; 46: 2822-2823
  • Schuhegger, R., R. Kugler, and A. Sing. Pitfalls with toxigenic Corynebacterium ulcerans causing diphtheria-like illness. Clin. Infect. Dis. 2008; 47: 288

Fallberichte und Epidemiologie

  • Martel, A., F. Boyen, J. Rau, T. Eisenberg, A. Sing, A. Berger, K. Chiers, S. van Praet, S. Verbanck, M. Vervaeke, and F. Pasmans. 2021. Widespread disease in hedgehogs (Erinaceus europaeus) caused by toxigenic Corynebacterium ulcerans. Emerg Infect Dis. 27:2686-2690
  • Schlez, K., T. Eisenberg, J. Rau, S. Dubielzig, M. Kornmayer, G. Wolf, A. Berger, A. Dangel, C. Hoffmann, C. Ewers, and A. Sing. 2021. Corynebacterium rouxii, a recently described member of the C. diphtheriae group isolated from three dogs with ulcerative skin lesions. Antonie Van Leeuwenhoek 114:1361-1371
  • Fuchs, F., D. Markert, I. Wagner, M. Liebau, A. Berger, A. Dangel, A. Sing, M. Fabri, and G. Plum. 2020. Toxigenic Corynebacterium diphtheriae-associated genital ulceration. Emerg Infect Dis. 26:2180-2181
  • Berger, A., A. Dangel, M. Peters, K. Mühldorfer, S. Braune, T. Eisenberg, C.A. Szentiks, J. Rau, R. Konrad, S. Hörmansdorfer, N. Ackermann, and A. Sing. 2019. Tox-positive Corynebacterium ulcerans in hedgehogs, Germany. Emerg Microbes Infect 8: 211-216

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