Auswahl von Publikationen aus dem Konsiliarlabor Diphtherie
Molekulare Charakterisierung
Dangel, A., A. Berger, J. Rau, T. Eisenberg, P. Kämpfer, G. Margos, M. Contzen, H.-J. Busse, R. Konrad, M. Peters, R. Sting, and A. Sing. 2020. Corynebacterium silvaticum sp. nov., a unique group of NTTB corynebacteria in wild boar and roe deer. Int J Syst Evol Microbiol. 70: 3614-3624 https://www.microbiologyresearch.org/content/journal/ijsem/10.1099/ijsem.0.004195#tab2
Rau, J., T. Eisenberg, M. Peters, A. Berger, P. Kutzer, H. Lassnig, H. Hotzel, A. Sing, R. Sting, and M. Contzen. 2019. Reliable differentiation of a non-toxigenic tox gene-bearing Corynebacterium ulcerans variant frequently isolated from game animals using MALDI-TOF MS. Vet Microbiol. 237:108399 https://www.sciencedirect.com/science/article/pii/S0378113519306224?via%3Dihub
Möller, J., M. Kraner, U. Sonnewald, V. Sangal, H. Tittlbach, J. Winkler, T.H. Winkler, V. Melnikov, R. Lang, A. Sing, A.L. Mattos-Guaraldi, and A. Burkovski. 2019. Proteomics of diphtheria toxoid vaccines reveals multiple proteins that are immunogenic and may contribute to protection of humans against Corynebacterium diphtheriae. Vaccine 37:3061-3070 https://www.sciencedirect.com/science/article/pii/S0264410X19305353?via%3Dihub
Meinel, D.M., G. Margos, R. Konrad, S. Krebs, H. Blum, and A. Sing. Next generation sequencing analysis of nine Corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin encoding pathogenicity island. Genome Medicine 2014; 6: 113 http://genomemedicine.com/content/6/11/113/abstract
König, C., D.M. Meinel, G. Margos, R. Konrad, and A. Sing. Multilocus Sequence Typing of Corynebacterium ulcerans provides evidence for zoonotic transmission and for increased prevalence of certain sequence types among toxigenic strains. J Clin Microbiol. 2014; 52:4318-4324 http://jcm.asm.org/content/52/12/4318.long
Bolt, F., P. Cassiday, M.L.Tondella, A. DeZoysa, A. Efstratiou, A. Sing, A. Zasada, K. Bernard, N. Guiso, E. Badell, M-L. Rosso, A. Baldwin, C. Dowson. Multilocus sequence typing identifies of evidence recombination and two distinct lineages within Corynebacterium diphtheriae. J. Clin. Microbiol. 2010; 48: 4177-4185 http://jcm.asm.org/content/48/11/4177.long
Sing, A., S. Bierschenk, and J. Heesemann. Classical diphtheria caused by Corynebacterium ulcerans in Germany: amino acid sequence differences between diphtheria toxins from C. diphtheriae and C. ulcerans. Clin. Infect. Dis. 2005; 40: 325-326 http://cid.oxfordjournals.org/content/40/2/325.long
Sing, A., M. Hogardt, S. Bierschenk, and J. Heesemann. Detection of differences in the nucleotide and aminoacid sequences of diphtheria toxin from Corynebacterium diphtheriae and Corynebacterium ulcerans causing extrapharyngeal infections. J. Clin. Microbiol. 2003; 41: 4848-4851 http://jcm.asm.org/content/41/10/4848.long
Marosevic, D., A. Berger, G. Kahlmeter, S. Payer, S. Hörmansdorfer, and A. Sing. 2020. Antimicrobial susceptibility of Corynebacterium diphtheriae and C. ulcerans in Germany 2011-2017. J Antimicrob Chemother 75: 2885-2893 https://academic.oup.com/jac/article/75/10/2885/5880199
Both, L, S. Neal, A.De Zoysa, G. Mann, I. Czumbel, A. Efstratiou, and Members of the European Diphtheria Surveillance Network. External quality assessments for microbiologic diagnosis of Diphtheria in Europe. J Clin Microbiol. 2014; 52:4381-4384 http://jcm.asm.org/content/52/12/4381.long
Von Hunolstein, C., L. Ralli, A. Pinto, P. Stickings, A. Efstratiou, I. Czumbel, A. Decheva, R, et al. Relevance and Criticality in an External Quality Assessment for the Determination of Diphtheria Antitoxin. J Immunol Clin Res 2014; 2(2): 1022 http://www.jscimedcentral.com/Immunology/immunology-2-1022.pdf
Berger, A., M. Hogardt, R. Konrad, and A. Sing. 2014. Detection methods for laboratory diagnosis of diphtheria. In: Burkovski, A. (ed.), Corynebacterium diphtheriae and related toxigenic species. Genomics, Pathogenicity and Applications. Springer-Verlag, Berlin-Heidelberg; p. 171-205
Sing, A., A. Berger, W. Schneider-Brachert, T. Holzmann, and U. Reischl. Rapid detection and molecular differentiation of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by LightCycler PCR. J. Clin. Microbiol. 2011; 49: 2485-2489 http://jcm.asm.org/content/49/7/2485.long
Berger, A., and A. Sing. 2010. Corynebacterium diphtheriae. In: Podbielski, A., A. Berger, S. Dommerich, M. Donat, H. Frickmann, W. Hampl, M. Hermann, H. Lang, H. Luckhaupt, M. Riffelmann, A. Sing, A. Spahr, U. Vogel, C. Wirsing von König: Mikrobiologisch-infektiologische Qualitätsstandards (MiQ) 13a und 13b: Infektionen des Mundes und der oberen Atemwege, Teil I und II . 2. neu bearbeitete Aufl., p 107-113
Konrad, R., A. Berger, I. Huber, V. Boschert, S. Hörmansdorfer, U. Busch, M. Hogardt, S. Schubert, and A. Sing. 2010. Matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) mass spectrometry as a tool for rapid diagnosis of potentially toxigenic Corynebacterium species in the laboratory management of diphtheria-associated bacteria. Euro Surveill 15: pii=19699 http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19699
Schuhegger, R., M. Lindermayer, R. Kugler, J. Heesemann, U. Busch, and A. Sing. Detection of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by a novel real-time PCR. J. Clin. Microbiol. 2008; 46: 2822-2823 http://jcm.asm.org/content/46/8/2822.long
Schuhegger, R., R. Kugler, and A. Sing. Pitfalls with toxigenic Corynebacterium ulcerans causing diphtheria-like illness. Clin. Infect. Dis. 2008; 47: 288 http://cid.oxfordjournals.org/content/47/2/288.long
Fallberichte und Epidemiologie
Martel, A., F. Boyen, J. Rau, T. Eisenberg, A. Sing, A. Berger, K. Chiers, S. van Praet, S. Verbanck, M. Vervaeke, and F. Pasmans. 2021. Widespread disease in hedgehogs (Erinaceus europaeus) caused by toxigenic Corynebacterium ulcerans. Emerg Infect Dis. 27:2686-2690 https://wwwnc.cdc.gov/eid/article/27/10/20-3335_article
Schlez, K., T. Eisenberg, J. Rau, S. Dubielzig, M. Kornmayer, G. Wolf, A. Berger, A. Dangel, C. Hoffmann, C. Ewers, and A. Sing. 2021. Corynebacterium rouxii, a recently described member of the C. diphtheriae group isolated from three dogs with ulcerative skin lesions. Antonie Van Leeuwenhoek 114:1361-1371 https://link.springer.com/article/10.1007/s10482-021-01605-8
Fuchs, F., D. Markert, I. Wagner, M. Liebau, A. Berger, A. Dangel, A. Sing, M. Fabri, and G. Plum. 2020. Toxigenic Corynebacterium diphtheriae-associated genital ulceration. Emerg Infect Dis. 26:2180-2181 https://wwwnc.cdc.gov/eid/article/26/9/18-0830_article
Berger, A., A. Dangel, M. Peters, K. Mühldorfer, S. Braune, T. Eisenberg, C.A. Szentiks, J. Rau, R. Konrad, S. Hörmansdorfer, N. Ackermann, and A. Sing. 2019. Tox-positive Corynebacterium ulcerans in hedgehogs, Germany. Emerg Microbes Infect 8: 211-216 https://www.tandfonline.com/doi/pdf/10.1080/22221751.2018.1562312?needAccess=true
Dangel, A., A. Berger, R. Konrad, H. Bischoff, and A. Sing. Geographically Diverse Clusters of Nontoxigenic Corynebacterium diphtheriae Infection, Germany, 2016-2017. Emerg Infect Dis. 2018;24:1239-1245 https://wwwnc.cdc.gov/eid/article/24/7/17-2026_article
Teutsch, B., A. Berger, D. Marosevic, K. Schönberger, T.-T. Lâm, K. Hubert, S. Beer, P. Wienert, N. Ackermann, H. Claus, M. Drayß, K. Thiel, M. van der Linden, U. Vogel, and A. Sing. Corynebacterium species nasopharyngeal carriage in asymptomatic individuals aged ≥ 65 years in Germany. Infection 2017; 45:607-611 https://link.springer.com/article/10.1007%2Fs15010-017-1017-0
Meinel, D.M., R. Kuehl, R. Zbinden, V. Boskova, C. Garzoni, D. Fadini, M. Dolina, B. Blümel, T. Weibel, S. Tschudin-Sutter, A.F. Widmer, J.A. Bielicki, A: Dierig, U. Heininger, R. Konrad, A. Berger, V. Hinic, D. Goldenberger, A. Blaich, T. Stadler, M. Battegay, A. Sing#, and A. Egli#. Outbreak investigation for toxigenic Corynebacterium diphtheriae wound infections in refugees from Northeast Africa and Syria in Switzerland and Germany by whole genome sequencing. Clin Microbiol Infect. 2016; 22:1003.e1-1003.e8 https://www.sciencedirect.com/science/article/pii/S1198743X16303305
Sing, A., R. Konrad, D.M. Meinel, N. Mauder, I. Schwabe, and R. Sting. Corynebacterium diphtheriae in a free-roaming red fox: case report and historical review on diphtheria in animals. Infection 2016; 44: 441-445 http://link.springer.com/article/10.1007%2Fs15010-015-0846-y
Eisenberg, T., N. Mauder, M. Contzen, J. Rau, C. Ewers, K. Schlez, G. Althoff, N. Schauerte, C. Geiger, G. Margos, R. Konrad, and A. Sing. Outbreak with clonally related isolates of Corynebacterium ulcerans in a group of water rats. BMC Microbiol 2015; 15:42 http://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-015-0384-x
Meinel, D.M., R. Konrad, A. Berger, C. König, T. Schmidt-Wieland, M. Hogardt, H. Bischoff, N. Ackermann, S. Hörmansdorfer, S. Krebs, H. Blum, G. Margos, and A. Sing. 2015. Zoonotic Transmission of toxigenic Corynebacterium ulcerans Strain, Germany, 2012. Emerg Infect Dis. 2015; 21: 356-358 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313654/
Sting, R., S. Ketterer-Pintur, M. Contzen, N. Mauder, A. Sing, and C. Süß-Dombrowski. Toxigenic Corynebacterium ulcerans isolated from a free-roaming red fox (Vulpes vulpes). Berl Munch Tierarztl Wochenschr 2015; 128: 10-14
Boschert, V., A. Berger, R. Konrad, I. Huber, S. Hörmansdorfer, S. Zöls, M. Eddicks, M. Ritzmann, and A. Sing. Corynebacterium spp. nasal carriage in pigs and their farmers in Bavaria, Germany: implications for public health. Vet Rec 2014; pii: vetrec-2014-102634. http://veterinaryrecord.bmj.com/content/175/10/248.long
Eisenberg, T., P. Kutzer, M. Peters, A. Sing, M. Contzen, and J. Rau. Non-Toxigenic tox-bearing Corynebacterium ulcerans infection in game animals in Germany. Emerg. Inf. Dis. 2014; 20: 448-452 http://wwwnc.cdc.gov/eid/article/20/3/pdfs/13-0423.pdf
Berger, A., C. Lensing, R. Konrad, I. Huber, M. Hogardt, and A. Sing. Sexually transmitted diphtheria. Sex Transm Infect 2013; 89: 100-101 http://sti.bmj.com/content/89/2/100.long
Berger, A., V. Boschert, R. Konrad, T. Schmidt-Wieland, S. Hörmansdorfer, M. Eddicks, and A. Sing. Two cases of cutaneous diphtheria associated with occupational pig contact in Germany. Zoonoses Public Health 2013; 60: 539-542 http://onlinelibrary.wiley.com/doi/10.1111/zph.12031/abstract
Berger, A., R. Konrad, H. Bischoff, S. Hörmansdorfer, and A. Sing. Diphtherie als Zoonose: zum Vorkommen toxigener Corynebakterien bei Mensch und Tier. Hyg Med 2013; 38: 300-305
Berger, A., T. Schmidt-Wieland, I. Huber, and A. Sing. Human diphtheria infection from a cat bite. Ann. Intern. Med. 2011; 155: 646-648 http://annals.org/article.aspx?articleid=1033145
Berger, A., I. Huber, S.-S. Merbecks, I. Ehrhard, R. Konrad, S. Hörmansdorfer, M. Hogardt, and A. Sing. Toxigenic Corynebacterium ulcerans in woman and cat. Emerg. Inf. Dis. 2011; 17: 1767-1768 http://wwwnc.cdc.gov/eid/article/17/9/11-0391_article
Schuhegger, R., C. Schoerner, J. Dlugaiczyk, I. Lichtenfeld, A. Trouillier, V. Zeller-Peronnet, U. Busch, A. Berger, R. Kugler, S. Hörmansdorfer, and A. Sing. Pigs as a source for toxigenic Corynebacterium ulcerans in diphtheria-like disease. Emerg. Inf. Dis. 2009; 15: 1314-1315 http://wwwnc.cdc.gov/eid/article/15/8/08-1568_article
Wellinghausen, N., A. Sing, W. V. Kern, S. Perner, R. Marre, and J. Rentschler. A fatal case of necrotizing sinusitis due to toxigenic Corynebacterium ulcerans. Int. J. Med. Microbiol. 2002; 292: 59-63 http://www.sciencedirect.com/science/article/pii/S1438422104702118
